Generating Vectors for the Lattice Structures of Tubular and Conical Viral Capsids

• Autorzy: Farrah Sadre-Marandi , Jiangguo Liu , Simon Tavener , Chaoping Chen
• Języki publikacji: EN

Abstrakty

EN

Retrovirus capsid is a fullerene-like lattice consisting of capsid protein hexamers and pentamers. Mathematical models for the lattice structure help understand the underlying biological mechanisms in the formation of viral capsids. It is known that viral capsids could be categorized into three major types: icosahedron, tube, and cone. While the model for icosahedral capsids is established and well-received, models for tubular and conical capsids need further investigation. This paper proposes new models for the tubular and conical capsids based on an extension of the Capser-Klug quasi-equivalence theory. In particular, two and three generating vectors are used to characterize respectively the lattice structures of tubular and conical capsids. Comparison with published HIV-1 data demonstrates a good agreement of our modeling results with experimental data.

Słowa kluczowe

EN

CA protein; capsid; cone; hexamer; HIV-1; icosahedron; pentamer; tube

• Wydawca: De Gruyter Open
• Czasopismo: Molecular Based Mathematical Biology
• Rocznik: 2014
• Tom: 2
• Numer: 1

Daty

otrzymano

2014-09-02

zaakceptowano

2014-11-08

online

2014-12-10

Twórcy

autor

Farrah Sadre-Marandi

• Department of Mathematics, Colorado State University, Fort Collins, CO 80523-1874, USA

autor

Jiangguo Liu

• Department of Mathematics, Colorado State University, Fort Collins, CO 80523-1874, USA

autor

Simon Tavener

• Department of Mathematics, Colorado State University, Fort Collins, CO 80523-1874, USA

autor

Chaoping Chen

• Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870, USA

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Identyfikatory

DOI

10.2478/mlbmb-2014-0009