Relative dielectric constants and selectivity ratios in open ionic channels

• Autorzy: Bob Eisenberg , Weishi Liu
• Języki publikacji: EN

Abstrakty

EN

We investigate the effects of the relative dielectric coefficient on ionic flows in open ion channels, using mathematical analysis of reasonably general Poisson-Nernst-Planck type models that can include the finite sizes of ions. The value of the relative dielectric coefficient is of course a crucial parameter for ionic behavior in general. Using the powerful theory of singularly perturbed problems in applied mathematics, we show that some properties of open channels are quite insensitive to variation in the relative dielectric coefficient, thereby explaining such effects seen unexpectedly in simulations. The ratio between the total number of one ion species and that of another ion species, and the ratio between the flux of one ion species and that of another ion species do not depend significantly on the relative dielectric coefficient.

Słowa kluczowe

EN

Poisson-Nernst-Planck models; relative dielectric coefficients; selectivity ratios

• Wydawca: De Gruyter Open
• Czasopismo: Molecular Based Mathematical Biology
• Rocznik: 2017
• Tom: 5
• Numer: 1
• Strony: 125-137

Daty

wydano

2017-10-26

otrzymano

2017-06-16

zaakceptowano

2017-09-26

online

2017-10-28

Twórcy

autor

Bob Eisenberg

• , Illinois 60612,

autor

Weishi Liu

• , Kansas 66045,

Identyfikatory

DOI

10.1515/mlbmb-2017-0008