In this note we present a proof of existence of global in time regular (unique) solutions to the Navier-Stokes equations in an arbitrary three dimensional domain with a general boundary condition. The only restriction is that the L₂-norm of the initial datum is required to be sufficiently small. The magnitude of the rest of the norm is not restricted. Our considerations show the essential role played by the energy bound in proving global in time results for the Navier-Stokes equations.