Different models of chemotherapy taking into account drug resistance stemming from gene amplification

• Autorzy: Jarosław Śmieja , Andrzej Świerniak
• Języki publikacji: EN

Abstrakty

EN

This paper presents an analysis of some class of bilinear systems that can be applied to biomedical modelling. It combines models that have been studied separately so far, taking into account both the phenomenon of gene amplification and multidrug chemotherapy in their different aspects. The mathematical description is given by an infinite dimensional state equation with a system matrix whose form allows decomposing the model into two interacting subsystems. While the first one, of a finite dimension, can have any form, the other is infinite dimensional and tridiagonal. A methodology of the analysis of such models, based on system decomposition, is presented. An optimal control problem is defined in the l^1 space. In order to derive necessary conditions for optimal control, the model description is transformed into an integro-differential form. Finally, biomedical implications of the obtained results are discussed.

Słowa kluczowe

EN

biomedical modelling; multivariable control; infinite dimensional systems

• Wydawca: University of Zielona Gora Press
• Czasopismo: International Journal of Applied Mathematics and Computer Science
• Rocznik: 2003
• Tom: 13
• Numer: 3
• Strony: 297-305

Daty

wydano

2003

otrzymano

2003-03-01

poprawiono

2003-06-01

Twórcy

autor

Jarosław Śmieja

• Department of Automatic Control, Silesian University of Technology, ul. Akademicka 16, 44-100 Gliwice, Poland

autor

Andrzej Świerniak

• Department of Automatic Control, Silesian University of Technology, ul. Akademicka 16, 44-100 Gliwice, Poland

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