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On the stability of neutral-type uncertain systems with multiple time delays

100%
EN
The problems of both single and multiple delays for neutral-type uncertain systems are considered. First, for single neutral time delay systems, based on a Razumikhin-type theorem, some delay-dependent stability criteria are derived in terms of the Lyapunov equation for various classes of model transformation and decomposition techniques. Second, robust control for neutral systems with multiple time delays is considered. Finally, we demonstrate numerical examples to illustrate the effectiveness of the proposed approaches. Compared with results existing in the literature, our methods are shown to be superior to them.
EN
In this paper, we analyse the local stability of a gene-regulatory network and immunotherapy for cancer modelled as nonlinear time-delay systems. A numerically generated kernel, using the sum-of-squares decomposition of multivariate polynomials, is used in the construction of an appropriate Lyapunov-Krasovskii functional for stability analysis of the networks around an equilibrium point. This analysis translates to verifying equivalent LMI conditions. A delay-independent asymptotic stability of a second-order model of a gene regulatory network, taking into consideration multiple commensurate delays, is established. In the case of cancer immunotherapy, a predator-prey type model is adopted to describe the dynamics with cancer cells and immune cells contributing to the predator-prey population, respectively. A delay-dependent asymptotic stability of the cancer-free equilibrium point is proved. Apart from the system and control point of view, in the case of gene-regulatory networks such stability analysis of dynamics aids mimicking gene networks synthetically using integrated circuits like neurochips learnt from biological neural networks, and in the case of cancer immunotherapy it helps determine the long-term outcome of therapy and thus aids oncologists in deciding upon the right approach.
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Design of the state predictive model following control system with time-delay

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EN
Time-delay systems exist in many engineering fields such as transportation systems, communication systems, process engineering and, more recently, networked control systems. It usually results in unsatisfactory performance and is frequently a source of instability, so the control of time-delay systems is practically important. In this paper, a design of the state predictive model following control system (PMFCS) with time-delay is discussed. The bounded property of the internal states for the control is given, and the utility of this control design is guaranteed. Finally, examples are given to illustrate the effectiveness of the proposed method, and state predictive control techniques are applied to congestion control synthesis problems for a TCP/AQM network.
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