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An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map

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Poteat M., He J.

Molecular Based Mathematical Biology

2017

tom 5

nr 1

31-39

Cryo-electron microscopy (Cryo-EM) is a powerful technique to produce 3-dimensional density maps for large molecular complexes. Although many atomic structures have been solved from cryo-EM density maps, it is challenging to derive atomic structures when the resolution of density maps is not sufficiently high. Geometrical shape representation of secondary structural components in a medium-resolution density map enhances modeling of atomic structures.We compare two methods in producing surface representation of the β-sheet component of a density map. Given a 3-dimensional volume of β-sheet that is segmented from a density map, the performance of a polynomial fitting was compared with that of an iterative Bézier fitting. The results suggest that the iterative Bézier fitting is more suitable for β-sheets, since it provides more accurate representation of the corners that are naturally twisted in a β-sheet.

Ograniczanie wyników

1 Molecular Based Mathematical Biology

1 He J.

1 Poteat M.

1 2017

Wyniki wyszukiwania

An Iterative Bézier Method for Fitting Beta-sheet Component of a Cryo-EM Density Map