A round anniversary is a reflection-friendly moment ... Like last year, I~would like to start with ``I can not believe that...'' This time, however, it will be more personally. Therefore -- I can not believe that it has been 25 years since I walked through the empty (yes, it is unbelievable as well!) streets of Zakopane to the resort where the First National Conference Applications of Mathematics to Biology and Medicine took place. At the end of my journey with quite a heavy backpack (clearly, you need to take the official, everyday and tourist outfit) I met only a hedgehog, which at that time was rather rare. Just at the entrance, participants were welcomed by Przemek Sypka, who participated in the organization of the first conferences, and at the same time created the logo that we use to this day. Another person I met there was Prof. Mariusz Ziółko -- initiator, chairman of the Scientific Committee and the only person who participated in all our conferences. My humble person ranks second in this ranking, as so far I missed only the conference in Mądralin, while the third one is Prof. Antoni Leon Dawidowicz, who was absent twice.