EN
Lotka-Volterra systems appear in population biology, plasma physics, laser physics and derivation theory, among many others. We determine the rings of constants of four-variable Lotka-Volterra derivations with four parameters C 1, C 2, C 3, C 4 ∈ k, where k is a field of characteristic zero. Thus, we give a full description of polynomial first integrals of the respective systems of differential equations.