Numerical simulation of surface acoustic wave actuated cell sorting

• Autorzy: Thomas Franke , Ronald Hoppe , Christopher Linsenmann , Kidist Zeleke
• Języki publikacji: EN

Abstrakty

EN

We consider the mathematical modeling and numerical simulation of high throughput sorting of two different types of biological cells (type I and type II) by a biomedical micro-electro-mechanical system (BioMEMS) whose operating behavior relies on surface acoustic wave (SAW) manipulated fluid flow in a microchannel. The BioMEMS consists of a separation channel with three inflow channels for injection of the carrier fluid and the cells, two outflow channels for separation, and an interdigital transducer (IDT) close to the lateral wall of the separation channel for generation of the SAWs. The cells can be distinguished by fluorescence. The inflow velocities are tuned so that without SAW actuation a cell of type I leaves the device through a designated outflow channel. However, if a cell of type II is detected, the IDT is switched on and the SAWs modify the fluid flow so that the cell leaves the separation channel through the other outflow boundary. The motion of a cell in the carrier fluid is modeled by the Finite Element Immersed Boundary method (FE-IB). Numerical results are presented that illustrate the feasibility of the surface acoustic wave actuated cell sorting approach.

Słowa kluczowe

EN

Surface acoustic wave actuated cell sorting; Biomedical micro-electro-mechanical system; Finite element immersed boundary method

Kategorie tematyczne

• 74L15: Biomechanical solid mechanics
• 76Z05: Physiological flows
• 92C50: Medical applications (general)
• 65M60: Finite elements, Rayleigh-Ritz and Galerkin methods, finite methods
• 92C10: Biomechanics

• Wydawca: De Gruyter Open
• Czasopismo: Open Mathematics
• Rocznik: 2013
• Tom: 11
• Numer: 4
• Strony: 760-778

Daty

wydano

2013-04-01

online

2013-01-29

Twórcy

autor

Thomas Franke

• University of Augsburg

autor

Ronald Hoppe

autor

Christopher Linsenmann

• University of Augsburg

autor

Kidist Zeleke

• University of Houston

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Identyfikatory

DOI

10.2478/s11533-012-0165-9