On any space-like Weingarten surface in the three-dimensional Minkowski space we introduce locally natural principal parameters and prove that such a surface is determined uniquely up to motion by a special invariant function, which satisfies a natural non-linear partial differential equation. This result can be interpreted as a solution to the Lund-Regge reduction problem for space-like Weingarten surfaces in Minkowski space. We apply this theory to linear fractional space-like Weingarten surfaces and obtain the natural non-linear partial differential equations describing them. We obtain a characterization of space-like surfaces, whose curvatures satisfy a linear relation, by means of their natural partial differential equations. We obtain the ten natural PDE’s describing all linear fractional space-like Weingarten surfaces.