All second order scalar differential invariants of symplectic hyperbolic and elliptic Monge-Ampère equations with respect to symplectomorphisms are explicitly computed. In particular, it is shown that the number of independent second order invariants is equal to 7, in sharp contrast with general Monge-Ampère equations for which this number is equal to 2. We also introduce a series of invariant differential forms and vector fields which allow us to construct numerous scalar differential invariants of higher order. The introduced invariants give a solution of the symplectic equivalence of Monge-Ampère equations. As an example we study equations of the form u xy + f(x, y, u x, u y) = 0 and in particular find a simple linearization criterion.