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Tytuł artykułu

Curvature Concentrations on the HIV-1 Capsid

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
It is known that the retrovirus capsids possess a fullerene-like structure. These caged polyhedral arrangements are built entirely from hexagons and exactly 12 pentagons according to the Euler theorem. Viral capsids are composed of capsid proteins, which create the hexagon and pentagon shapes by groups of six (hexamer) and five (pentamer) proteins. Different distributions of these 12 pentamers result in icosahedral, tubular, or conical shaped capsids. These pentamer clusters introduce declination and hence curvature on the capsids. This paper provides explicit and quantitative characterization of curvature on virus capsids. The concept of curvature concentration is also introduced. For the HIV (5,7)-cone, it is shown that the curvature concentration at the narrow end is about at least four times higher than that at the broad end. Our modeling results about curvature concentrations on HIV-1 capsids echo the results in the literature that the pentamers are in the regions with the highest stress, although the connection between the two approaches (curvature concentration and stress) is to be explored. This also leads to a conjecture that “HIV-1 capsid narrow end may close last during maturation but open first during entry into a host cell".
Słowa kluczowe
EN
Wydawca
Rocznik
Tom
3
Numer
1
Opis fizyczny
Daty
otrzymano
2014-12-07
zaakceptowano
2015-06-08
online
2015-07-21
Twórcy
autor
  • Department of Mathematics, Colorado State University, Fort Collins, CO 80523-1874,
    USA
  • Department of Mathematics, Colorado State University, Fort Collins, CO 80523-1874,
    USA
  • Department of Mathematics, Colorado State University, Fort Collins, CO 80523-1874,
    USA
  • Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1870,
    USA
Bibliografia
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Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.doi-10_1515_mlbmb-2015-0003
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