The study of coupled system of hybrid fractional differential equations (HFDEs) needs the attention of scientists for the exploration of its different important aspects. Our aim in this paper is to study the existence and uniqueness of mild solution (EUMS) of a coupled system of HFDEs. The novelty of this work is the study of a coupled system of fractional order hybrid boundary value problems (HBVP) with n initial and boundary hybrid conditions. For this purpose, we are utilizing some classical results, Leray–Schauder Alternative (LSA) and Banach Contraction Principle (BCP). Some examples are given for the illustration of applications of our results.