A comparison between the continual reassessment method andD-optimum design for dose finding in phase I clinical trials

• Autorzy: M. Iftakhar Alam
• Języki publikacji: EN

Abstrakty

EN

The continual reassessment method is a model-based procedure, described in the literature, used to determine the maximum tolerated dose in phase I clinical trials. The maximum tolerated dose can also be found under the framework of D-optimum design, where information is gathered in such a way so that asymptotic variability in the parameter estimates in minimised. This paper investigates the two methods under some realistic settings to explore any potential differences between them. Simulation studies for six plausible dose-response scenarios show that D-optimum design can work well in comparison with the continual reassessment method in many cases. The D-optimum design is also found to allocate doses from the extremes of the design region to the patients in a trial.

Słowa kluczowe

EN

Dose finding studies; Phase I trial; Maximum tolerated dose; Continual reassessment method; D-optimum design

• Wydawca: De Gruyter Open
• Czasopismo: Biometrical Letters
• Rocznik: 2016
• Tom: 53
• Numer: 2
• Strony: 69-82

Daty

wydano

2016-12-01

online

2016-12-10

Twórcy

autor

M. Iftakhar Alam

• Institute of Statistical Research and Training, University of Dhaka, Dhaka-1000,

Identyfikatory

DOI

10.1515/bile-2016-0006