Czasopismo
Tytuł artykułu
Warianty tytułu
Języki publikacji
Abstrakty
The scheduling of angiogenic inhibitors to control a vascularized tumor is analyzed as an optimal control problem for a mathematical model that was developed and biologically validated by Hahnfeldt et al. [Cancer Res. 59 (1999)]. Two formulations of the problem are considered. In the first one the primary tumor volume is minimized for a given amount of angiogenic inhibitors to be administered, while a balance between tumor reduction and the total amount of angiogenic inhibitors given is minimized in the second formulation. The optimal solutions to both problems are presented and compared.
Słowa kluczowe
Kategorie tematyczne
Czasopismo
Rocznik
Tom
Numer
Strony
295-312
Opis fizyczny
Daty
wydano
2009
Twórcy
autor
- Department of Mathematics and Statistics, Southern Illinois University at Edwardsville, Edwardsville, IL 62026-1653, U.S.A.
autor
- Department of Mathematics and Statistics, Southern Illinois University at Edwardsville, Edwardsville, IL 62026-1653, U.S.A.
autor
- Department of Electrical, and Systems Engineering, Washington University, St. Louis, MO 63130-4899, U.S.A.
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
DOI
Identyfikator YADDA
bwmeta1.element.bwnjournal-article-doi-10_4064-am36-3-4