Identifiability and estimation of pharmacokinetic parameters for the ligands of the macrophage mannose receptor

• Autorzy: Nathalie Verdiere , Lilianne Denis-Vidal , Ghislaine Joly-Blanchard , Dominique Domurado
• Języki publikacji: EN

Abstrakty

EN

The aim of this paper is numerical estimation of pharmacokinetic parameters of the ligands of the macrophage mannose receptor, without knowing it a priori the values of these parameters. However, it first requires a model identifiability analysis, which is done by applying an algorithm implemented in a symbolic computation language. It is shown that this step can lead to a direct numerical estimation algorithm. In this way, a first estimate is computed from noisy simulated observations without it a priori parameter values. Then the resulting parameter estimate is improved by using the classical least-squares method.

Słowa kluczowe

EN

identifiability; biological applications; nonlinear systems; parameter estimation

• Wydawca: University of Zielona Gora Press
• Czasopismo: International Journal of Applied Mathematics and Computer Science
• Rocznik: 2005
• Tom: 15
• Numer: 4
• Strony: 517-526

Daty

wydano

2005

otrzymano

2004-12-20

poprawiono

2005-07-19

(nieznana)

2005-09-15

Twórcy

autor

Nathalie Verdiere

• Department Genie Informatique, University of Technology of Compiegne, BP 20 529, 60 205 Compiegne Cedex, France

autor

Lilianne Denis-Vidal

• University of Sciences and Tech., Lille, France

autor

Ghislaine Joly-Blanchard

• Department Genie Informatique, University of Technology of Compiegne, BP 20 529, 60 205 Compiegne Cedex, France

autor

Dominique Domurado

• CRBA - Faculty of Pharmacy, BP 14 491, 34093 Montpellier Cedex 5, France

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