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Identifiability and estimation of pharmacokinetic parameters for the ligands of the macrophage mannose receptor

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Verdiere N., Denis-Vidal L., Joly-Blanchard G., Domurado D.

International Journal of Applied Mathematics and Computer Science

2005

tom 15

nr 4

517-526

The aim of this paper is numerical estimation of pharmacokinetic parameters of the ligands of the macrophage mannose receptor, without knowing it a priori the values of these parameters. However, it first requires a model identifiability analysis, which is done by applying an algorithm implemented in a symbolic computation language. It is shown that this step can lead to a direct numerical estimation algorithm. In this way, a first estimate is computed from noisy simulated observations without it a priori parameter values. Then the resulting parameter estimate is improved by using the classical least-squares method.

Ograniczanie wyników

1 International Journal of Applied Mathematics and Computer Science

1 Denis-Vidal L.

1 Domurado D.

1 Joly-Blanchard G.

1 Verdiere N.

1 2005

Wyniki wyszukiwania

Identifiability and estimation of pharmacokinetic parameters for the ligands of the macrophage mannose receptor